Company Overview

Harbour BioMed (HKEX: 02142) is a global biopharmaceutical company committed to the discovery and development of novel antibody therapeutics in immunology, oncology and other areas. The Company is building a robust portfolio and differentiated pipeline through internal R&D capability, strategic global collaborations in co-discovery and co-development, and selective acquisitions.

Our proprietary antibody technology platform, Harbour Mice®, generates fully human monoclonal antibodies in both the conventional two heavy and two light chain (H2L2) format and the heavy chain-only (HCAb) format. Building upon HCAb antibodies, the HCAb-based immune cell engagers (HBICE®) bispecific antibody technology enables tumor-killing effects that traditional combination therapies cannot achieve. The HCAb-based Antibody Plus technology (HCAb PLUSTM) provides comprehensive modality solutions for the development of innovative multi-specific medicines in different disease areas. Additionally, building upon the Harbour Mice® platform, Harbour BioMed launched its first fully human Generative AI HCAb Model powered by its Hu-mAtrIxTM AI platform, accelerating the development of innovative therapies.

By integrating Harbour Mice®, HBICE®, HCAb PLUSTM, a single B-cell cloning platform and AI technologies, Harbour BioMed has built a highly efficient and distinctive antibody discovery engine for developing next-generation therapeutic antibodies. 

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Harbour Mice®

Our proprietary antibody technology platforms Harbour Mice® generate fully human antibodies. The platforms have broad potential for generating both conventional as well as the Next-Gen biologics that are fully human, affinity matured with excellent solubility and developability.

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Pipeline
Inflammatory & Immunology Diseases
Project(Partners)
Target
Indication
Region
Discovery
Preclinical
IND
PH1
PH2
PH3
BLA Filing
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Batoclimab HBM9161

FcRn

Myasthenia Gravis

Greater China
(Out-Licensed)

HBM9378

TSLP

Asthma

COPD*

Greater China
(Ex-GC: NewCo)

Greater China
(Ex-GC: NewCo)

HBM7575

TSLP×
Undisclosed

Inflammatory Diseases

Global

HBM2001

TL1A×IL23p19

IBD

Global

J9003

Undisclosed
(mAb)

IBD

Global

R1065

APRIL

IgAN

Global

OX40L Family

OX40L×
Undisclosed

Dermatosis

Global

Pathogenic B Cell Depletion for Autoimmune Diseases

HBM7020

BCMA×CD3

Autoimmune Diseases

Global
(Out-Licensed)

R2006

CD19×CD3

Autoimmune Diseases

Global

R7027

Undisclosed
(bsAb)

Autoimmune Diseases

Global

Oncology/Immuno-Oncology
Project(Partners)
Target
Indication
Region
Discovery
Preclinical
IND
PH1
PH2
PH3
BLA Filing
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Porustobart HBM4003

CTLA-4

Melanoma

CRC*

HCC*

NEN*

Greater China
(Ex-GC: NewCo)

Greater China
(Ex-GC: NewCo)

Greater China
(Ex-GC: NewCo)

Greater China
(Ex-GC: NewCo)

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HBM1020

B7H7/HHLA2

Solid Tumors

Global

Next-Generation Therapeutics

HBM7022

CLDN18.2×CD3

Solid Tumors

Global
(Out-Licensed)

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HBM7008

B7H4×4-1BB

NSCLC

Global

HBM9027

PD-L1×CD40

Pancreatic Cancer

Global

HBM7004

B7H4×CD3

NSCLC

Global

HBM9033

MSLN
(ADC)

Solid Tumors

Global
(Out-Licensed)

Weight Management
Project(Partners)
Target
Indication
Region
Discovery
Preclinical
IND
PH1
PH2
PH3
BLA Filing

LET003

Undisclosed
(mAb)

Obesity

Global

LET001

Undisclosed
(LYTAC)

Obesity

Global

  • PD1 / Chemo

  • Breakthrough Therapy Designation

* CRC = Colorectal Cancer

* HCC = Hepatocellular Carcinoma

* NEN = Neuroendocrine Neoplasm

* COPD = Chronic Obstructive Pulmonary Disease

Partnership Models

Partnerships are integral to Harbour BioMed's strategy to build a fully integrated biopharmaceutical company. Harbour BioMed has built up global R&D centers within USA, Europe and China.

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