About Us

Committed to Improving Patients’ Life

Company Overview

Harbour BioMed is a global, clinical stage biopharmaceutical company committed to the discovery, development and commercialization of novel antibody therapeutics in the areas of oncology and immunological diseases to address unmet patient’s needs.


We are building a robust pipeline with our integrated Harbour antibody platform, that enable us to develop highly differentiated antibodies against various disease targets with great potency and safety profiles. Our proprietary Harbour Mice® generate fully human monoclonal antibodies in the classical two heavy and two light chain (H2L2) format, as well as heavy chain only (HCAb) format. Building upon our HCAb antibodies, the HCAb-based immune cell engagers (HBICETM) are capable of delivering tumor killing effects unachievable by combination therapies. Integrated with our single B cell cloning platform, our antibody discovery engine is highly unique and efficient for development of next generation therapeutic antibodies.  

  1. Our Vision

    Innovative Medicines for Healthy Life.

  2. Our Mission

    To Become the Leading Company Driving Global Innovation of NextGen Antibody Therapeutics.

HBM’s efforts are driven by our vision of delivering “Innovative Medicines for Healthy Life”. To realize this vision, we have been partnering with global academic institutions, biotechnology and pharmaceutical companies by leveraging our platforms. We have established a strong track record of portfolio includes strategically selected co-development clinical assets and internal innovative NextGen projects to address unmet patient’s need. We also provide technology licensing for our proprietary Harbour antibody technologies to accelerate the industry innovation on antibody therapeutics.

Corporate Strategy

Our strategic priorities are focused on driving global inventions of transformative next generation medicines powered by our proprietary technology platforms and data driven science.

 

Immunotherapies have been increasingly recognized as critical components of evolving treatment paradigms owing to the superior efficacy and safety profiles. However, the current standards of care in oncology and immunological diseases fall short owing to complexities of these multicomponent, multifactorial diseases, thereby limiting the response and outcomes in most patient populations.

 

With a strong patient-centric approach, we combine the power of Harbour Mice® with other advanced technologies, like single B cell cloning, bispecific antibody, bioinformatics and translational research to generate and identify lead antibody candidates to treat diseases. Our highly efficient antibody discovery engine ensures sustainable innovation in order to develop a diversified and balanced pipeline of potentially first-in-class and/or best-in-class cutting-edge immunology and IO therapies, both independently, and through collaborations with global pharmaceutical and research institutions. Our HCAb and HBICETM platforms allow us to design unique and novel formats of antibodies, including bi- and multi-specific antibodies, that aim to exponentially enhance the clinical efficacy and safety of these candidates which are unachievable by combination therapies. We aspire to lead the next wave of immunotherapies in oncology and immunology.

 

Our portfolio also consists of strategically selected, in-licensed and risk-mitigated clinical assets with near-term revenue potential targeting diseases with high unmet need. Batoclimab (HBM9161) and tanfanercept (HBM9036) are the two anchor assets in this portfolio, and both of them are well positioned as the first mover to address significant unmet needs in their respective addressable markets in China.

  1. Oncology
    Oncology

    Oncology

    The human tumor microenvironment is a unique bionetwork of heterogeneous collection of tumor cells along with different kind of immune cells, myeloid cells, lymphocytes, and a repertoire of signaling molecules. Approaches so far resulting into standard of care have met with limited success owing to several different factors including, but not limited to, access to the TME, heterogeneity of mechanisms involved with tumors, amongst others. Through rigorous biomarker analyses and artificial intelligence (machine learning) we aim to identify and establish the right immunotherapy for the right patient populations that would boost treatment outcomes. Targeting the immune cell engager pathways our HBICE approach is directed towards combining early and late stage immune engagers to prime and target the tumors for immediate and complete elimination. With a multi-pronged antibody (HBICE) approach to identify novel targets and mechanisms with in the TME, our goal is to transform cancer treatment paradigm by enabling the body’s own immune system to attack these tumors and bring long-term benefits to patients.

  2. Immunological Diseases
    Immunological Diseases

    Immunological Diseases

    We focus on niche conditions with high unmet medical needs where a unique antibody approach combined with new or known targets may offer a meaningful therapeutic solution with a long-lasting impact for patients suffering from these conditions.

Our History

July 09, 2020
May 04, 2020
March 12, 2020
March 06, 2020
February 28, 2020
February 21, 2020
October 11, 2019
July 10, 2019
May 06, 2019
January 22, 2019
September 21, 2018
August 27, 2018
August 07, 2018
January 23, 2018
December 26, 2016

July 09, 2020

Harbour BioMed Raises $102.8M in Series C Financing to Accelerate Development of Its Innovative Portfolio of Next Generation Biologics

Harbour BioMed Raises $102.8M in Series C Financing to Accelerate Development of Its Innovative Portfolio of Next Generation Biologics

May 04, 2020

Utrecht University, Erasmus Medical Center and Harbour BioMed Researchers Report Discovery of Antibody that Blocks Novel Coronavirus SARS-CoV-2 Infection in Cells

Utrecht University, Erasmus Medical Center and Harbour BioMed Researchers Report Discovery of Antibody that Blocks Novel Coronavirus SARS-CoV-2 Infection in Cells

March 12, 2020

Harbour BioMed Raises $75 Million Series B2 Venture Capital Financing to Accelerate Its Innovative Pipeline

Harbour BioMed Raises $75 Million Series B2 Venture Capital Financing to Accelerate Its Innovative Pipeline

March 06, 2020

Mount Sinai and Harbour BioMed Collaborate to Advance Novel Biotherapies for the Treatment of Cancer and Coronavirus COVID-19

Mount Sinai and Harbour BioMed Collaborate to Advance Novel Biotherapies for the Treatment of Cancer and Coronavirus COVID-19

February 28, 2020

Harbour BioMed Announces U.S. FDA Approval of IND for Its Next Generation anti-CTLA-4 Antibody, HBM4003, to Treat Cancer

Harbour BioMed Announces U.S. FDA Approval of IND for Its Next Generation anti-CTLA-4 Antibody, HBM4003, to Treat Cancer

February 21, 2020

Harbour BioMed Announces Completion of Phase 1 Study in China of HBM9161, an Anti-FcRn Antibody

October 11, 2019

Harbour BioMed Announces Completion of Phase 2 Study of HBM9036 in Patients with Moderate-to-Severe Dry Eye Disease in China

Harbour BioMed Announces Completion of Phase 2 Study of HBM9036 in Patients with Moderate-to-Severe Dry Eye Disease in China

July 10, 2019

Yinuoke and Harbour BioMed Announce A Strategic Alliance to Develop Innovative Biologics to Address Unmet Patients' Needs

Yinuoke and Harbour BioMed Announce A Strategic Alliance to Develop Innovative Biologics to Address Unmet Patients' Needs

May 06, 2019

Harbour BioMed and Chia Tai Tianqing Pharmaceutical Group Ltd. Announce Strategic Alliance to Discover, Develop and Commercialize Innovative Biologics

Harbour BioMed and Chia Tai Tianqing Pharmaceutical Group Ltd. Announce Strategic Alliance to Discover, Develop and Commercialize Innovative Biologics

January 22, 2019

Harbour BioMed integrates the Beacon® Platform to Accelerate Antibody Discovery

Harbour BioMed integrates the Beacon® Platform to Accelerate Antibody Discovery

September 21, 2018

Harbour BioMed Receives Approval to Start the Phase II Clinical Trial of Its Innovative Drug Candidate for The Treatment of Inflammatory Eye Disease

Harbour BioMed Receives Approval to Start the Phase II Clinical Trial of Its Innovative Drug Candidate for The Treatment of Inflammatory Eye Disease

August 27, 2018

Harbour BioMed Raises $85 Million in Series B Financing to Accelerate Its Innovative Pipeline

Harbour BioMed Raises $85 Million in Series B Financing to Accelerate Its Innovative Pipeline

August 07, 2018

Harbour BioMed and Glenmark Pharmaceuticals Sign Agreement for Greater China to Develop GBR 1302, a First-in-Class Bispecific Antibody for Treatment of HER2-Positive Cancers

Harbour BioMed and Glenmark Pharmaceuticals Sign Agreement for Greater China to Develop GBR 1302, a First-in-Class Bispecific Antibody for Treatment of HER2-Positive Cancers

January 23, 2018

Harbour BioMed Completes Series A3 Round Financing to Accelerate the Development of Clinical Programs and Company Growth

Harbour BioMed Completes Series A3 Round Financing to Accelerate the Development of Clinical Programs and Company Growth

December 26, 2016

Harbour BioMed Established

Harbour BioMed Established

Management Team

Jingsong Wang

Jingsong Wang

MD, PhD
Founder, Chairman and Chief Executive Officer

Mr. Jingsong Wang, M.D., Ph.D., is our Principal Founder, Chairman and Chief Executive Officer. Prior to founding our company, Dr. Wang served as Head of China R&D and Head of Translational Medicine, Asia Pacific, at Sanofi. He is a former attending physician and clinical fellow at Harvard Medical School. Dr. Wang received his Ph.D. in Molecular Pharmacology from China Pharmaceutical University and has also completed a Molecular Immunology Research Fellowship at Dr. Laurie Glimcher ’s laboratory at the Harvard School of Public Health.

Xiaoxiang Chen

Xiaoxiang Chen

MD
Chief Development Officer

Mr. Xiaoxiang Chen, M.D., is our Chief Development Officer. Prior to Harbour BioMed, Mr. Chen served as Vice President of Medicine at Medicine and Regulatory department at Boehringer Ingelheim. Prior to that, Mr. Chen was Director of Clinical Research at Wyeth Asia Pacific R&D Center.

Amy Que

Amy Que

PhD
Chief Technology Officer

Ms. Amy Que, Ph.D., is our Chief Technology Officer. Prior to Harbour BioMed, Dr. Amy served as Senior VP, Project Management and Alliance Management at Innovent Biologics, Executive Director at Wuxi Biologics. She also worked as Scientist / Principal Scientist at Genetech and Pfizer.

 

Yingying Chen

Yingying Chen

PhD, MBA
Chief Financial Officer

Ms. Yingying Chen, Ph.D., is our Chief Financial Officer. Prior to Harbour BioMed, Ms. Chen served as Managing Director, Head of Healthcare at GF Investments Hong Kong and CMBC International, leading these organizations’ Healthcare investments. Prior to that, she worked at multiple global bulge bracket investment banks covering Healthcare clients, including UBS Investment Bank New York, Royal Bank of Scotland/ABN AMRO Bank Hong Kong, and Deutsche Bank Hong Kong.

Lile Liu

Lile Liu

Senior Vice President, Head of Technology Platform

Mr. Lile Liu, is our Senior Vice President, Head of Technology Platform and Head of Suzhou Operations. Prior to joining our Company, Mr. Liu served as Vice President of Biologics Discovery at ChemPartner. Prior to that, Mr. Liu served as Operational Vice President, Antibody Division, at GenScript.

Yiping Rong

Yiping Rong

PhD
Head of Discovery Biology

Mr. Yiping Rong, Ph.D., is our Head of Discovery Biology. Prior to joining Harbour BioMed, Dr. Rong served as Associate Director of Cancer Research at Sanofi Asia Pacific R&D Center. Prior to that, Dr. Rong was Group Leader of Translational Research in Janssen Discovery Center and Project Leader of Biologics Discovery in Roche R&D.

Jingsong Wang
Xiaoxiang Chen
Amy Que
Yingying Chen
Lile Liu
Yiping Rong

Scientific Advisory Board

Frank Grosveld

Frank Grosveld

PhD
Academy Professor of Cell Biology, Erasmus Medical Center, Rotterdam
Founding Chief Scientific Officer, Harbour BioMed

Frank Grosveld, Ph.D., has served on our scientific advisory board since December 2016. Dr. Grosveld is Co-founder and CSO of Harbour Antibodies and the inventor of Harbour Mice®, Professor and former Head of Department of Cell Biology and Department of Clinical Genetics at Erasmus University Medical Center, Rotterdam, a fellow of Royal Society and a member of Royal Netherlands Academy of Arts and Sciences. Dr. Grosveld’s research on the control of globin gene expression has been selected as one of the top ten achievements of Medical Research Council (UK) (MRC) in the 20th century by Higher Education and Research Opportunities in the U.K. Dr. Grosveld was awarded the Louis-Jeantet Prize for Medicine in 1991, the Spinozapremie (Spinoza Prize) in 1995.

Robert Kamen

Robert Kamen

PhD
Entrepreneur in Residence, Venture Partner at Third Rock Ventures, Independent non-Executive Director of HBM

Robert Kamen, Ph.D., has served on our scientific advisory board since 2016. Dr. Kamen is a Venture Partner at Third Rock Ventures. In 2005, he co-founded BioAssets Development Corporation and served as its Chairman. He currently serves as an independent non-executive Director of the Company and a director of Jounce Therapeutics (NASDAQ:JNCE). He was previously a director of Neon Therapeutics and Harbour Antibodies. Earlier in his career, he was senior vice president of scientific affairs at the pioneering biotechnology firm named Genetics Institute, Inc.. Dr. Kamen received his bachelor ’s degree in biophysics from Amherst College, a Ph.D. in biochemistry and molecular biology from Harvard University Graduate School of Arts and Sciences. During his academic scientific career, he worked at the Imperial Cancer Research Fund.

Kenneth Murphy

Kenneth Murphy

MD, PhD
Eugene Opie First Centennial Professor of Pathology & Immunology, Washington University School of Medicine, Investigator, Howard Hughes Medical Institute, Member, US National Academy of Sciences

Kenneth Murphy, M.D., Ph.D., has served on our scientific advisory board since June 2019. Dr. Murphy is the Eugene Opie First Centennial Professor of Pathology & Immunology, Washington University School of Medicine in St. Louis, and a Member of the National Academy of Sciences. Dr. Murphy was awarded the William B. Coley Award for Distinguished Research in Basic Immunology by Cancer Research Institute in 2012 and the AAI-Thermo Fisher Meritorious Career Award by Thermo Fisher Scientific in 2016. Dr. Murphy received his bachelor degree in chemistry from Rice University and a Ph.D. in pharmacology and M.D. from Hopkins University School of Medicine.

Zhigang Tian

Zhigang Tian

PhD
Member of Chinese Academy of Engineering, Professor at University of Science and Technology of China (USTC), Director of Institute of Immunology of USTC, Director of The Key Lab of Innate Immunity and Chronic Diseases of Chinese Academy of Science, and President of the school of Basic Medicine

Zhigang Tian, Ph.D., has served on our scientific advisory board since August 2020. Dr. Tian is a member of Chinese Academy of Engineering and a medical immunologist. Currently, he is a professor at University of Science and Technology of China (USTC), where he also works as a Director of Institute of Immunology, Director of The Key Lab of Innate Immunity and Chronic Diseases of Chinese Academy of Science, and President of the school of Basic Medicine, and the former dean of School of Life Sciences of USTC. Dr. Tian was awarded with The National Science Fund for Distinguished Young Scholars. He is the academic leader of Chang Jiang Scholars Program as well as the Innovation Research Program of National Natural Science Foundation of China. Dr. Tian is Head of National Science and Technology Major Project and Chief Scientist of National Major Research Plan Program.

Dr. Zhigang Tian’s laboratory is credited with seminal discoveries regarding basic knowledge and clinical study of natural killer (NK) cells, particularly liver-resident NK cells, cytokine-producing NK cells, and NK cell-based immunotherapy.

Robert Kramer

Robert Kramer

PhD
CSO of SalvaRx Therapeutics; BoD, Meditope Bioscience; Chair, NeoTx SAB; Member, Servier Pharma, Aro Biotherapeutics and Crown Biosciences SAB

Robert Kramer, Ph.D., has served on our scientific advisory board since December 2016. Dr. Kramer serves as CSO of Portage Biotech Inc. Dr. Kramer previously served as Vice President and Head of Discovery for Oncology Therapeutics at Janssen Research & Development, LLC (the Pharmaceutical Division of Johnson and Johnson), where he was responsible for leading Global Discovery, focusing on aberrant signaling cascades in tumor cells, as well as epigenetic reprogramming and tumor immunology using both small molecule and protein-based large molecule approaches. Prior to joining Janssen Research & Development, LLC, Dr. Kramer served as VP Drug Discovery and Research for Bristol-Myers Squibb (BMS), where he provided scientific leadership and strategic oversight for many pre-clinical Oncology and Immunology programs and projects that entered development. Dr. Kramer was previously an Assistant Professor at Harvard Medical School. Dr. Kramer received his Ph.D. in pharmacology from the University of Vermont and completed his post-doctoral fellowship in Oncology at the National Cancer Institute, National Institutes of Health.

Peter Moesta

Peter Moesta

PhD
Chief CMC Advisor at Harbour BioMed, Former CEO, Adello Biologics

Peter Moesta, Ph.D., has served on our scientific advisory board since December 2016. He oversaw the development, production and worldwide launch of important medicines, such as Humira, Yervoy and Opdivo. Dr. Moesta previously served in executive roles at Bristol-Myers Squibb.

Jon Marc Wigginton

Jon Marc Wigginton

MD
Chief Medical Officer at Cullinan Oncology, Advisor at PMP Capital

Jon Marc Wigginton, M.D., has served on our scientific advisory board since May 2020. Dr. Wigginton currently serves as Chief Medical Officer, Cullinan Oncology, and Advisor, MPM Capital. He previously served as Chief Medical Officer and Senior Vice President of Clinical Development at MacroGenics, Inc., a Maryland biotechnology company focused on immunotherapeutic approaches for cancer and autoimmune disease. Prior to MacroGenics, Dr. Wigginton served as Therapeutic Area Head of Immuno-Oncology, Early Clinical Research at Bristol-Myers Squibb (BMS), where he led the early clinical development of the BMS Immuno-Oncology portfolio including anti-PD-1, anti-PD-L1 and various immunotherapy combinations including anti-CTLA-4/anti-PD-1 among others. During his academic career, Dr. Wigginton held several positions at the National Cancer Institute, Center for Cancer Research (NCI-CCR), including Head of Investigational Biologics Section, Pediatric Oncology Branch, where he led an integrated basic, translational and early clinical research effort focused on combination immunotherapy. Dr. Wigginton also previously served as President of the Society for Immunotherapy of Cancer.