Therapeutics
Developing Next Generation Therapeutics for Healthy Life
Pipeline
Immunology
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Product(Partners)TargetIndicationRegionDiscoveryPreclinicalINDPH1PH2PH3BLA Filing
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Batoclimab HBM9161(HanAll)
FcRn
MG*
NMOSD*
TED*
ITP*
CIDP*
PV*
Greater
ChinaGreater
ChinaGreater
ChinaGreater
ChinaGreater
ChinaGreater
China -
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Tanfanercept HBM9036(Hanall)
TNFα
Dry Eye Disease
Greater
China -
HBM9378
TSLP
Asthma
Global
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HBM9022(AbbVie; Utrecht University; Erasmus MC)
SARS-COV-2
COVID-19
Global License to AbbVie
Oncology/Immnuo-Oncology
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Product(Partners)TargetIndicationRegionDiscoveryPreclinicalINDPH1PH2PH3BLA Filing
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HBM4003
CTLA-4
Advanced Solid Tumors
Advanced Melanoma & Other Solid Tumors
Advanced NSCLC & Other Solid Tumors
Global
Global
Global
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HBM7022
Claudin18.2xCD3
Solid Tumors
Global License to AstraZeneca
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HBM1007
CD73
Solid Tumors
Global
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HBM7020
BCMAxCD3
Multiple Myeloma
Ex-Greater China
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HBM7008
B7H4x4-1BB
Solid Tumors
Global
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HBM1022
CCR8
Solid Tumors
Global
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HBM1020
B7H7
Solid Tumors
Global
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HBM
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Partner
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Registrational Clinical Trial
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Monotherapy
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PD1 / Chemo
Greater China rights out-licensed to Hualan Genetics
* MG = Myasthenia Gravis
* NMOSD = Neuromyelitis Optica Spectrum Disorder
* ITP = Immune Thrombocytopenic Purpura
* TED = Thyroid Eye Disease
* CIDP = Chronic Inflammatory Demyelinating Polyradiculoneuropathy
* PV = Pemphigus Vulgaris
* HCC = Hepatocellular Carcinoma
* NEN = Neuroendocrine Neoplasms
* NSCLC = Non-Small Cell Lung Cancer
Publications
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An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile
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TNF-α inhibitor tanfanercept (HBM9036) improves signs and symptoms of dry eye in a phase 2 trial in the controlled adverse environment in China
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Therapeutic Response and Possible Biomarkers in Acute Attacks of Neuromyelitis Optica Spectrum Disorders: A Prospective Observational Study
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of HBM9161, a novel FcRn inhibitor, in a phase I study for healthy Chinese volunteers
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SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model
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A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
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Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes
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A human monoclonal antibody blocking SARS-CoV-2 infection
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Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
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Cell Engager Summit Exclusive Speaker Interview
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Preclinical evaluation of HBM7022, an HBICE™ 2+1 CLDN18.2 x CD3 bispecific antibody, for gastric cancer
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Development of fully human T-cell engaging bispecific antibodies targeting B7H4
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Discovery of potent and functional human antibodies against a new B7-family member, B7H7, for cancer immunotherapy
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HCAb Based Bispecific Immune Cell Engager (HBICE) Platform Enables Fast And Convenient Generation of the Next Generation Bispecific Antibodies with High Potency, Promising Safety Profiles and Excellent Developability
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HBM1022, a Novel Anti-CCR8 Antibody, Depletes Tumor-infiltrating Regulatory T cells via Enhanced ADCC Activity, Mediates Potent Anti-Tumor Activity
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Novel Monoclonal Antibodies (mAbs) Targeting Human CCR8 Provide Potential Candidates for Next Generation Cancer Immunotherapy
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HBM1007 – A Highly Potent Anti-CD73 mAb Candidate For Mono And Combination IO Therapy
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BCMA x CD3 Bispecific Antibody – A novel HBICE™-based Molecule with Efficient Tumor Killing and Minimal Cytokine Release
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A New Generation of Fully Human anti-CTLA-4 Heavy Chain Only Antibody
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