August, 31, 2020, Shanghai, China – Harbour BioMed, a global, clinical-stage, innovative biopharmaceutical company, today announced that it presented  its newly developed  HBICE^TM (HCAb Based Immune Cell Engager) platform and its ability to generate fast and reliable next-generation bispecific antibodies for immunotherapies at the 16th PEGS Boston Summit. The poster will be presented through a voice-over presentation on August 31. The 16th PEGS Boston Summit will take place virtually, from August 31 to September 4, 2020.

The HCAb platform can generate diverse and stable fully human HCAbs derived human VH single-domain moieties, that allow for the design of novel multi-specific and multi-valent antibodies in simplified structures with relatively smaller molecule size and fewer number of polypeptide chains. Leveraging the technology know-how, we accumulated on our HCAb, we have independently developed the HBICE^TM Platform, which focuses on generating highly differentiated HCAb-based immune cell engagers capable of delivering tumor-killing effects unachievable by combination therapies.

As the only proven bispecific mechanism of action in oncology, immune cell engagers engage patients’ own immune cells to identified tumor-specific antigen cells, with the goal of activating the cytotoxic potential of immune cells to fight cancers. Compared with other bispecific formats for immune cell engagers bispecifics generated on HBICE^TM platform are able to address multiple criteria critical to clinical activity of bispecifics. The versatile geometry designs based on biology MoAs, fully human amino-acid sequences, intact Fc-mediated long half-life and other unique properties make HBICE^TM an effective and efficient bispecific or multi-specific antibody platform.

HBICE^TM enables the facile development of products with attributes not achievable by conventional antibody platforms or a simple combination of two monoclonal antibodies. In this poster we demonstrate how the HBICE^TM platform generates high efficiency Tumor Associated Antigen(TAA) x 4-1BB bispecific antibodies, which co-stimulate T Cells, inhibit tumor growth and maintain an improved safety profile comparing to other conventional monoclonal antibodies. Several additional targets based on this platform are currently in discovery and preclinical stages of development. 

About HCAb

HCAb's patented technology generates novel "heavy chain only" antibodies, which are about half the size of a typical IgG. These antibodies carry IgG-like PK properties and Fc-domain functions without the need for additional engineering or humanization. Lack of light chain also minimizes the problem of light chain mispairing and heterodimerization. These characteristics enable the development of products with attributes not achievable by conventional antibody platforms. In addition, various formats, including single-domain antibodies, bi- and multi-specifics, antibody-drug conjugates, CAR-Ts or VH domain-derived diagnostic or therapeutic products, are also achievable using this platform.

About Harbour BioMed

 
Harbour BioMed (HKEX: 02142) is a global biopharmaceutical company committed to the discovery, development and commercialization of novel antibody therapeutics focusing on oncology and immunology. The Company is building its robust portfolio and differentiated pipeline through internal R&D capability, collaborations with co-discovery and co-development partners and select acquisitions.

 
The Company’s proprietary antibody technology platforms Harbour Mice^® generate fully human monoclonal antibodies in two heavy and two light chain (H2L2) format, as well as heavy chain only (HCAb) format. Building upon the HCAb antibodies, the HCAb-based immune cell engagers (HBICE^®) are capable of delivering tumor killing effects unachievable by traditional combination therapies. Integrating Harbour Mice^® with single B cell cloning platform, our antibody discovery engine is highly unique and efficient for development of next generation therapeutic antibodies.  

For further information, please refer to www.harbourbiomed.com