Harbour BioMed is a global clinical-stage biopharmaceutical company committed to the discovery, development and commercialization of novel antibody therapeutics in oncology and immunological disease areas to address unmet patient's needs.
We are building a robust pipeline with our integrated Harbour antibody platform, that enable us to develop highly differentiated antibodies against various disease targets with great potency and safety profiles. Our proprietary Harbour Mice® generate fully human monoclonal antibodies in the classical two heavy and two light chain (H2L2) format, as well as heavy chain only (HCAb) format. Building upon our HCAb antibodies, the HCAb-based immune cell engagers (HBICE®) are capable of delivering tumor killing effects unachievable by combination therapies. Integrated with our single B cell cloning platform, our antibody discovery engine is highly unique and efficient for development of next generation therapeutic antibodies.
HBM's efforts are driven by our vision of delivering “Healthy life · Breakthrough Medicines”. To realize this vision, we have been partnering with global academic institutions, biotechnology and pharmaceutical companies by leveraging our platforms. We have established a strong track record of portfolio includes strategically selected co-development clinical assets and internal innovative NextGen projects to address unmet patient' s need. We also provide technology licensing for our proprietary Harbour antibody technologies to accelerate the industry innovation on antibody therapeutics.
Our proprietary antibody technology platforms Harbour Mice® generate fully human antibodies. The platforms have broad potential for generating both conventional as well as the Next-Gen biologics that are fully human, affinity matured with excellent solubility and developability.
Porustobart HBM4003
CTLA-4
Melanoma
CRC*
HCC*
NEN*
Global
Global
Global
Global
HBM1020
B7H7/HHLA2
Solid Tumors
Global
HBM1022
CCR8
Solid Tumors
Global
HBM9014
LIFR
Solid Tumors
Global
HBM7022
CLDN18.2×CD3
Solid Tumors
Global Out-License
HBM7008
B7H4×4-1BB
Solid Tumors
Global
HBM7020
BCMA×CD3
Hematologic Carcinoma
Ex-China
HBM9027
PD-L1×CD40
Solid Tumors
Global
HBM7004
B7H4×CD3
Solid Tumors
Global
HBM9033
MSLN ADC
Solid Tumors
Global Out-License
ADC Program
Undisclosed
Solid Tumors
Global
RDC Program
Undisclosed
Solid Tumors
Global
Batoclimab HBM9161
FcRn
Myasthenia Gravis
Great China Rights Out-Licensed
HBM9378
TSLP
Asthma
COPD*
Global
Global
BsAb Programs
TSLP×
Undisclosed
Inflammatory Diseases
Global
HBM7020
BCMA×CD3
Autoimmune Diseases
Ex-China
TCE Program
CD19×CD3
Autoimmune Diseases
Global
BsAb Program
Undisclosed
Autoimmune Diseases
Global
TsAb Program
Undisclosed
Autoimmune Diseases
Global
PD1 / Chemo
Breakthrough Therapy Designation
* CRC = Colorectal Cancer
* HCC = Hepatocellular Carcinoma
* NEN = Neuroendocrine Neoplasm
* COPD = Chronic Obstructive Pulmonary Disease
Partnerships are integral to Harbour BioMed's strategy to build a fully integrated biopharmaceutical company. Harbour BioMed has built up global R&D centers within USA, Europe and China.
Harbour BioMed is interested in combining its discovery capabilities, including its own Harbour Mice® (transgenic mice) Platform Technology, for generating fully human antibodies, and its expertise in clinical development, with potential partners’ unique resources and expertise to co-discovery/co-development biotherapeutics.
Utilizing the world renowned Harbour Mice® Platform Technology, Harbour BioMed has discovered many best-in-class, first-in-class therapeutic candidates that are in different stages of development. Out-Licensing of certain programs allows Harbour BioMed to maximize the value of our assets and concentrate on certain programs, while ensuring patients to have access to all potential therapeutics.
The Harbour Mice® Platform Technology, which includes both the H2L2 and HCAb transgenic mice platforms, have been widely used by over 40 companies and academic institutions. The platforms were engineered to produce high quality, highly diverse and fully human antibodies, through natural process of in vivo maturation from carefully selected human immunoglobulin transgenes.
Currently, there are at least 6 antibodies that are generated from our H2L2/HCAb platforms and have entered into human clinical trials. Besides, over 200 therapeutic candidates discovered from the H2L2/HCAb platforms are in pre-clinical study stages.
Combining the Harbour Mice® Platform Technology with academic institutes' core strengths in early stage research and discovery is an innovative way to rapidly move attractive therapeutic candidates into the next phase of clinical development.
With highly selected partners who have unique knowledge and insights on special diseases or technology areas, we may choose to create joint ventures with them to explore highly innovative programs to address high unmet medical needs. We have initiated a few JV projects with an aim for broad technology and resource pooling and collaboration in the joint discovery, development and commercialization of the assets generated on our Harbour antibody platforms for treatment of rare diseases.
Company Overview
Harbour Mice
Pipeline
Partnership Models
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